HPLC of Formula: 1134-35-6In 2020 ,《Synthesis of the first mixed ligand Mn (II) and Cd (II) complexes of 4-methoxy-pyridine-2-carboxylic acid, molecular docking studies and investigation of their anti-tumor effects in vitro》 appeared in Applied Organometallic Chemistry. The author of the article were Tamer, Oemer; Mahmoody, Hayatullah; Feyzioglu, Kagan Fehmi; Kilinc, Olca; Avci, Davut; Orun, Oya; Dege, Necmi; Atalay, Yusuf. The article conveys some information:
The first mixed ligand Mn(II) and Cd(II) complexes containing 4-methoxy-pyridine-2-carboxylic acid (4-mpic) and 4,4′-dimethyl-2,2′-bipyridine (dmbpy) were synthesized. The geometric structures of [Mn(4-mpic)2(dmbpy)] (complex 1) and [Cd(4-mpic)2(dmbpy)] (complex 2) were determined by single crystal x-ray diffraction method. FTIR and UV-visible spectra were also recorded to study vibrational and electronic properties of complexes 1 and 2. D. functional theory (DFT) calculations were also carried out to provide a deep understanding in geometric, spectroscopic, electronic and nonlinear optical (NLO) properties of complexes 1 and 2. The first-order hyperpolarizability (β) parameter calculated as 332.9736 × 10-30 esu demonstrated that complex 1 is an extremely promising candidate to NLO materials. Natural bond orbital (NBO) anal. not only verified the distorted octahedral geometries of central metal ions, but also found out the high-energy interactions responsible for biol. activities for complexes 1 and 2. Anti-cancer activities of complexes 1 and 2 were tested on human breast carcinoma cell line MCF-7 (ER and PR pos., HER2 neg.) and the triple neg. breast carcinoma cell line MDA-MB 231 (ER, PR and HER2 neg.). Dose-response relation derived from MTT assays indicates that complexes 1 and 2 are showing concentration-dependent effects, which could suggest a potential use for these drug combinations in cancer cell lines. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6)
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.