Formula: C5H3Br2NIn 2019 ,《The development of improved syntheses of PPARγ-sparing, insulin sensitizing thiazolidinedione-ketones》 was published in Tetrahedron Letters. The article was written by Tanis, Steven P.; Colca, Jerry R.; Parker, Timothy T.; Artman, Gerald D. III; Larsen, Scott D.; Gadwood, Robert C.; Zeller, James R.. The article contains the following contents:
Ketones I [R = H, OMe; R1 = H, Et; Y = C(O); X = CH, N] were selected for clin. development, however their initial syntheses were considered suboptimal for application deep into clin. trials. Direct ketone introduction/maintenance was desired for maximum efficiency and convergence was found to be critically dependent upon the acidity of the nucleophilic species I [R = OMe; R1 = H; X = CH; Y = CHOH] and 1-(5-Ethyl-2-pyridinyl)-ethanone and the use of pre- or post-alkylative oximino-ether/oxime protection. Improvements in overall yield for the syntheses of compound I [R = H; R1 = Et; Y = C(O); X = N] from 20% to 44% and compound I [R = OMe; R1 = H; Y = C(O); X = CH] from 31% to 59% were realized. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Formula: C5H3Br2N)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Formula: C5H3Br2N