Formation of non-natural 伪,伪-disubstituted amino esters via catalytic Michael addition was written by Teegardin, Kip A.;Gotcher, Lacey;Weaver, Jimmie D.. And the article was included in Organic Letters in 2018.COA of Formula: C5F5N The following contents are mentioned in the article:
The enolate monoanion of amino esters is explored, and the first catalytic Michael addition of 伪-amino esters is demonstrated. These studies indicate that the acidity of the 伪C-H is the primary factor determining reactivity. Thus, polyfluorophenylglycine amino esters yield novel 伪-amino esters in the presence of a catalytic amount of a guanidine-derived base and Michael acceptors. Reactivity requires an acidic N-H, which is accomplished using common protecting groups such as N-Bz, N-Boc, and N-Cbz. Calculations and labeling experiments provide insight into the governing principles in which a key C-to-N proton transfer occurs, resulting in an expansion of the scope to include a number of natural amino esters. The study culminates with a late-stage functionalization of peptidic 纬-secretase inhibitor, DAPT. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3COA of Formula: C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C5F5N