Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto published the artcile< The reactions of some halogenated pyridines with methoxide and methanethiolate ions in dimethylformamide>, Application of C6H6ClNO, the main research area is pyridine dihalo substitution methoxide alkanethiolate; halopyridine substitution methoxide alkanethiolate; substitution dihalopyridine methoxide alkanethiolate; mercaptopyridine; alkylthiopyridine.
Dihalopyridines I (R = 2-Br, R1 = 5-, 6-Br; R = 2-, 5-Cl, R1 = 3-Cl) reacted with NaSR2 (R2 = Me, CHMe2) in DMF to give 73-96% mono- or bis-substitution products I (R = SR2) or I (R = R1 = SR2), depending upon reaction conditions. The dihalo compounds reacted with NaOMe to give 72-93% I (R = OMe), but bis-substitution occurred easily only for I (R = 2-Br, R1 = 6-Br; R = 5-Cl, R1 = 3-Cl). Some I [R(R1) = OMe, R1(R) = SMe] were prepared by further reaction of monosubstitution products. I (R = R1 = SCHMe2 were fragmented by Na-HMPA to give I (R = R1 = SH), which were isolated as I (R = R1 = SMe) in 63-80% yield.
Tetrahedron published new progress about Nucleophilic aromatic substitution reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Application of C6H6ClNO.