Application of 10177-29-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 10177-29-4, Name is 4-Chloronicotinic acid, SMILES is ClC1=CC=NC=C1C(=O)O, belongs to pyridine-derivatives compound. In a article, author is Chen, Zhiwei, introduce new discover of the category.
Synthesis, antiviral activity, and 3D-QSAR study of novel chalcone derivatives containing malonate and pyridine moieties
Several novel chalcone derivatives containing malonate and pyridine moieties were synthesized, and their structures were confirmed by H-1 nuclear magnetic resonance, C-13 nuclear magnetic resonance, F-19 nuclear magnetic resonance, infrared, and elemental analyses. Antiviral bioassays revealed that most of the compounds exhibited good antiviral activity against cucumber mosaic virus (CMV) at 500 mu g/mL. In particular, compounds 5l and 5n showed significant curative activities against CMV in vivo with 50% effective concentration (EC50) values of 186.2 and 211.5 mu g/mL, respectively; these values are even better than that of ningnanmycin (330.5 mu g/mL). A 3D quantitative structure-activity relationship study was carried out using the comparative molecular field analysis technique based on curative activities against CMV. Results revealed good predictive ability with cross-validated q(2) and non-cross-validated r(2) values of 0.517 and 0.990, respectively. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Application of 10177-29-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 10177-29-4.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem