Recently I am researching about SOFT-TISSUE INFECTIONS; VANCOMYCIN RESISTANCE; PERMEABILITY BARRIER; MEDICINAL CHEMISTRY; ESCHERICHIA-COLI; SKIN; MECHANISMS; EMERGENCE; THERAPY; DRUG, Saw an article supported by the Network of Antimicrobial Resistance in Staphylococcus aureus (NARSA) program under NIAID/NIH [HHSN272200700055C]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R35 GM128570, P30 CA023168]; Eli LillyEli Lilly; AmgenAmgen; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [P30CA023168] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R35GM128570] Funding Source: NIH RePORTER. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Kyei-Baffour, K; Mohammad, H; Seleem, MN; Dai, MJ. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Name: 3-Pyridinecarboxaldehyde
Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds. Structure-activity relationship of the first-generation aryl isonitrile compounds we synthesized led to an initial lead molecule that informed the synthesis of a second-generation of aryl isonitriles. From this new series of 20 compounds, three analogues inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA) (from 1 to 4 mu M) and were safe to human keratinocytes. Compound 19, with an additional isonitrile group exhibited improved activity against MRSA compared to the first-generation lead compound. This compound emerged as a candidate worthy of further investigation and further reinforced the importance of the isonitrile functionality in the compounds’ anti-MRSA activity. In a murine skin wound model, 19 significantly reduced the burden of MRSA, similar to the antibiotic fusidic acid. In summary, 19 was identified as a new lead aryl isonitrile compound effective against MRSA.
Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kyei-Baffour, K; Mohammad, H; Seleem, MN; Dai, MJ or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem