An article Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin WOS:000562941200012 published article about PROTECTS; TRAFFICKING; ENANTIOMERS; INHIBITION in [Abdelkafi, Hajer; Michau, Aurelien; Ngadjeua, Flora; Clerget, Alexandra; Caramelle, Lucie; Gillet, Daniel; Barbier, Julien] Univ Paris Saclay, Dept Medicaments & Technol Sante DMTS, SIMoS, CEA,INRAE, F-91191 Gif Sur Yvette, France; [Pons, Valerie; Ouarab, Lilia Ait; Buisson, David-Alexandre; Montoir, David; Cintrat, Jean-Christophe] Univ Paris Saclay, Dept Medicaments & Technol Sante DMTS, SCBM, CEA,INRAE, F-91191 Gif Sur Yvette, France in 2020.0, Cited 23.0. HPLC of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.
HPLC of Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem