Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 894086-00-1, is researched, SMILESS is CC(P(C1=CC=NN1C2=C(C3=CC=CC=C3)N(C4=CC=CC=C4)N=C2C5=CC=CC=C5)C(C)(C)C)(C)C, Molecular C32H35N4PJournal, Topics in Organometallic Chemistry called Process Economics and Atom Economy for Industrial Cross Coupling Applications via LnPd(0)-Based Catalysts, Author is Slack, Eric D.; Tancini, Peter D.; Colacot, Thomas J., the main research direction is lanthanum palladium catalysts economics atom economy process.Safety of 5-(di-tert-Butylphosphino)-1′,3′,5′-triphenyl-1’H-1,4′-bipyrazole.
Up to and beyond the 2010 Nobel Prize in Chem., Pd-based cross coupling has seen a boom in industrial applications and scientific research. These efforts have yielded a wealth of information on Pd-based catalyst technol. that can be separated into two broad categories: pre-catalysts and in situ generated catalysts. Proper selection of the catalyst system, i.e., in situ vs pre-catalyst is although process dependent, herein we provide an in-depth look into the often overlooked benefits of the pre-catalyst technol. for maximizing the process economics. Although ligands play a crucial role in catalysis, it is not “”all about ligands′ alone. To improve the efficiency of the process one may need to precisely generate the active catalytic species for that particular reaction. In this chapter, we highlighted this concept by providing industrial case studies where switching from in situ generated to pre-catalyst technol. yielded significant process economic benefits. We also provided process chemists with a methodol. to properly evaluate catalyst technol. and make recommendations on potential benefits by weighing the pros and cons of using in situ vs preformed.
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