Reference of 127561-18-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 127561-18-6, name is 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine. A new synthetic method of this compound is introduced below.
A-9 (0.33g, 1.40mmol), C-1 (0.30g, 1.30mmol),Triethylamine Anhydrous(0.263 g, 2.60 mmol) was dissolved in 25 mL of anhydrous acetonitrile, and HATU (0.513 g, 1.40 mmol) was added, and the reaction was performed at room temperature for 30 min. After the reaction, it was diluted with water, extracted with ethyl acetate, washed with dilute hydrochloric acid, washed with sodium bicarbonate solution, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, concentrated and purified by silica gel column chromatography (PE: EA = 2: 1, v / v) to obtain 470.385 g of the compound with a yield of 66.6%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,127561-18-6, 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, and friends who are interested can also refer to it.
Reference:
Patent; Hangzhou Weitan Pharmaceutical Technology Co., Ltd.; Cheng Yunfeng; Hu Yongzhou; (45 pag.)CN110357833; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem