Adding a certain compound to certain chemical reactions, such as: 1152617-24-7, 3-Chloro-4-iodopyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1152617-24-7, blongs to pyridine-derivatives compound. Product Details of 1152617-24-7
Step b: To a solution of 3-amino-5-chloropyrazine-2-thiol (100 mg, 0.619 mmol), 3-chloro-4-iodopyridin-2- amine (315 mg, 1.238 mmol), XantPhos (35.8 mg, 0.062 mmol), and Pd2(dba)3 (28.3 mg, 0.03 mmol) in dioxane (3 mE) was added (at RT and under N2) DIPEA (324 IL, 1.856 mmol). The resulting solution was stirred in a microwave reactor for 2.5 h at 100 C. After cooling to RT, the reaction was diluted with EtOAc and it was filtered through a pad of Celite with EtOAc (10 mE). The combined filtrates were concentrated and the resulting residue was purified by silica chromatography (0 to 5% gradient of MeOH/DCM) to give 3-((2-amino-3-chloropyridin-4-yl)thio)-6-chloropyrazin-2-amine (180 mg, 0.627 mmol). ?H NMR (400 MHz, METHANOE-d4) oe ppm 7.88 (s, 1H), 7.68 (d, J=5.56 Hz, 1H), 6.06 (d, J=5.56 Hz, 1H), 1.35-1.43 (m, 2H). MS mlz288.2 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1152617-24-7, 3-Chloro-4-iodopyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; Chen, Zhuoliang; Dore, Michael; Fortanet, Jorge Garcia; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Williams, Sarah; Sendzik, Martin; (63 pag.)US2017/1975; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem