115473-15-9, Adding a certain compound to certain chemical reactions, such as: 115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 115473-15-9, blongs to pyridine-derivatives compound.
To a reaction flask equipped with a stirrer, a condenser and a thermometer was added 19.2 g of 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one, which was then dispersed in 80 mL dichloromethane and cooled to 0 C. under stirring. 30.4 g of triethylamine were added to the mixture. After addition of 15.2 g of 3-cyanobenzyl bromide to the reaction system in batches, the reaction mixture was heated to reflux and continued to react for 5 h (completion of the reaction was monitored by TLC). The reaction liquid was washed with water (3¡Á80 mL). Then the dichloromethane layer was separated, fully dried over anhydrous sodium sulfate, and filtered. The dichloromethane was evaporated off under reduced pressure to obtain 20.8 g light yellow solid product (HPLC: 96.4%). Rf=0.45 [single point, developing solvent: v (petroleum ether): v (ethyl acetate)=1:2]. MS, m/Z: 270.0 (M).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115473-15-9, its application will become more common.
Reference:
Patent; TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH; LIU, Dengke; LIU, Ying; YUE, Nan; CHEN, Furong; TAN, Chubing; ZHOU, Yunsong; LIU, Peng; ZHAO, Yigui; ZHI, Deguang; LIU, Mo; LIU, Bingni; HUANG, Changjiang; TANG, Lida; US2013/72521; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem