Related Products of 1221171-88-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1221171-88-5, name is 5-(Trifluoromethoxy)pyridin-2-amine, molecular formula is C6H5F3N2O, molecular weight is 178.11, as common compound, the synthetic route is as follows.
Int-82 (200 mg, 1.12 mmol) was dissolved in DCM (10 mL) and a solution of Nbromosuccinimide (200 mg, 1.12 mmol) in DCM (5 mL) was added dropwise. The mixture was stined at rt for 16 h. The solvent was removed under reduced pressure and the residue was purified by colunm chromatography on silica gel using a mixture of petroleum ether and EtOAc (2:1) as eluent to give 3-bromo-5-(trifluoromethoxy)pyridin-2-amine (int-83) (200 mg, 69%) as a yellow solid. MS (ESI): mlz 257.9 [M+Hj.
Statistics shows that 1221171-88-5 is playing an increasingly important role. we look forward to future research findings about 5-(Trifluoromethoxy)pyridin-2-amine.
Reference:
Patent; ACTAVALON, INC.; DNEPROVSKAIA, Elena V.; HOLZWARTH, Michael S.; (160 pag.)WO2018/81612; (2018); A1;,
Pyridine – Wikipedia,
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