Reference of 126053-15-4, Adding some certain compound to certain chemical reactions, such as: 126053-15-4, name is 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol,molecular formula is C8H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 126053-15-4.
A solution of intermediate 38 (0.92 mmol), 4-chloro-6,7-dihydro- 5/-/-cyclopenta[b]pyridin- 7-ol (1 mmol), hydrogen chloride in dioxane 4M (46mul) in CH3CN (10ml) was heated at 65C for 5 hours. K2CO3 10% aqueous solution and EtOAc were added. The reaction mixture was extracted, the organic layer was separated, dried over MgSO4, filtered and evaporated. The residue (0.4g) was purified by high-performance liquid chromatography (Stability Silica 5mum 150×30. Omm). Mobile phase (NH4OH 0.2%; gradient CH2CI2/CH3OH from 98/2 to 88/12), yielding 49mg compound 63 and 114mg of compound 64.
According to the analysis of related databases, 126053-15-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/37308; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem