Application of 130722-95-1, Adding some certain compound to certain chemical reactions, such as: 130722-95-1, name is 3-(Benzyloxy)-5-bromopyridine,molecular formula is C12H10BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 130722-95-1.
3-Benzyloxy-5-bromopyridine (4.73 g, 18.0 mmol) was dissolved in tetrahydrofuran (25 rnL) and cooled to 0 0C.Isopropylmagnesiumchloride (10 mL, 2.0 M in THF) was syringed in and the reaction mixture was stirred for 2 hrs at room temperature. N.N-dimethylformamide (3 mL) in tetrahydrofuran (10 mL) was added and stirring was continued for an additional hour. The solution was quenched with 2 N HCl to pH of 3 then partitioned between ethyl acetate and water. The organic layer was separated and concentrated to give a residue which was purified using flash chromatography to give 3-benzyloxy-5-formylpyridine (2.00 g, 53%) as white solid. 1H NMR (DMSO-^6): delta 10.1 (s, IH), 8.72 (d, IH), 8.66 (d, IH), 7.84 (m, IH), 7.42-7.48 (m, 5H), 5.28 (s, 2H).
According to the analysis of related databases, 130722-95-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2007/84560; (2007); A2;,
Pyridine – Wikipedia,
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