13472-85-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13472-85-0, name is 5-Bromo-2-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.
Example 4: Synthesis of 3-(5-hydroxy-3-(2-methyl-2-propylthio)-l-[4[(2-methoxypyridin-5-yl)benzyl]- indol-2-yl-2,2-dimethyl-propionic acid ethyl ester (R = -CH2CH3; X = Br). Ethyl 3-(3-(tert-butylthio)-5-hydroxy-l-(4-(4,4J5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzyl)-lH- indol-2-yl)-2,2-dimethylpropionate (675g, 1.2 mol), 5-bromo-2-methoxypyridine (280.5g, 1.5 mol), Pd(PPh3)4(23.63g, 0.02 mol), and K2CO3 (412g) were added to a reactor containing 6.75 L of DME and 3.38 L of water and stirred. Nitrogen gas was bubbled into the mixture for about 20 minutes. The mixture was then heated to between 80 to 85 0C and stirred overnight. TLC analysis (EtO Ac/Petroleum ether = 1/5) showed the reaction had reached completion. The mixture was subsequently cooled to ambient temperature. Following cooling, the compound was extracted three times with EtOAc. The organic layer was then washed with water, followed by a brine wash. The organic layer was then dried with sodium sulfate, the solid removed by filtration and the organic layer was then concentrated in vacuo, affording 653 g of product in near quantitative yield.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13472-85-0, 5-Bromo-2-methoxypyridine.
Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; WO2009/55721; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem