Reference of 135450-23-6 ,Some common heterocyclic compound, 135450-23-6, molecular formula is C7H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stilTed solution of 1H-indole-3-carboxaldehyde (145.2mg, lmmol) and 6- (chloromethyl)picolinonitrile (167.8mg, l.lmmol) in 5.0 mL of MeCN was added Cs2CO3(980mg, 3mmol) at room temperature. The mixture was then heated to 80C and kept stirring for 3h. When 1H-indole-3-carboxaldehyde was consumed monitored by TLC, MeCN was evaporated. The residue was partitioned in 15 mL of water and 15 mL of ethyl acetate. The aqueous layer was extracted with ethyl acetate three times. The combined organic extracts were washed with brine, dried, and concentrated. The crudeproduct was purified by silica gel colunrn chromatography to give 6-((3 -formyl- 1 H-indol1-yl)methyl)picolinonitrile (214mg, 82% yield).ESI-MS mlz 262.1 [M+H].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 135450-23-6, 6-(Chloromethyl)-2-cyanopyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES; JIANG, Baishan; HU, Langxi; CUI, Yan; DING, Sheng; (29 pag.)WO2015/192343; (2015); A1;,
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