16867-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16867-03-1, name is 2-Amino-3-hydroxypyridine, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: Polyphosphoric acid (10 g) was added to the mixture of 2-aminophenols(or 2-aminothiols or 2-phenylenediamines) 2 (7-9 mmol,1.0 eq) and carboxylic acids 3 (1.0 eq) at room temperature and heatedto 170 C (dissolution of reactants in polyphosphoric acid and effectivestirring was observed at elevated temperatures). The reaction mixturewas stirred at 170 C for 3 h and was then allowed to cool to roomtemperature. The viscous reaction mixture was slowly diluted by icewater(200 mL), neutralized (to pH 7) by saturated solution of NaHCO3and extracted with multiple portions of ethyl acetate (3¡Á50 mL). Thecombined organic extracts were washed with brine (50 mL), dried oversodium sulfate (30 g), filtered and concentrated to yield compounds 4in 24-91% yields as colored solids.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16867-03-1, 2-Amino-3-hydroxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ankenbruck, Nicholas; Kumbhare, Rohan; Naro, Yuta; Thomas, Meryl; Gardner, Laura; Emanuelson, Cole; Deiters, Alexander; Bioorganic and Medicinal Chemistry; vol. 27; 16; (2019); p. 3735 – 3743;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem