The important role of 17282-00-7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17282-00-7, 3-Bromo-5-methylpyridin-2-amine.

Electric Literature of 17282-00-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17282-00-7, name is 3-Bromo-5-methylpyridin-2-amine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 154: 3-bromo-N-(5-chloro-2-methoxyphenyl)-5-methylpyridin-amine; 154 155156 157[0473] In a oven dried 50 mL round bottom flask were sequentially added 4-chloro-2- iodo-1-methoxybenzen (1.13 g, 4.2 mmol), 3-bromo-5-methylpyridin-2-amine (945 mg, 5.05 mmol), Pd2(dba)3 (192 mg, 0.21 mmol), xantphos (146 mg, 0.06 mmol) and Na’BuO (605 mg, 6.3 mmol) at room temperature. The solid materials were kept under vacuum for5 min. and then refilled with nitrogen. This process was repeated thrice before adding dry, EPO degassed dioxane (10 mL). The heterogeneous mixture was stirred at room temperature for 15 min. and then at 1000C for Ih. Finally upon completion of the reaction, it was diluted with ether and filtered through a small pad of silica gel with several washings. All the washings and filtrate concentrated in vacuum and the crude residue was further purified by flash chromatography to provide title compound (1.16 g, 84%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17282-00-7, 3-Bromo-5-methylpyridin-2-amine.

Reference:
Patent; TAKEDA SAN DIEGO, INC.; DAS, Sanjib; WO2007/44779; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem