Reference of 182275-70-3, Adding some certain compound to certain chemical reactions, such as: 182275-70-3, name is 2-Iodo-6-methoxypyridine,molecular formula is C6H6INO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 182275-70-3.
(-)-P7C3-S243: (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline: (S)-9-(3- amino-2-fluoropropyl)-3,6-dibromo-9H-carbazole (72.2 mg, 0.18 mmol), 2-iodo-6-methoxypyridine 45.4 mg, 0.19 mmcl), copper iodide (2.9 mg, 0.015 mmcl) and cesium carbonate (119.4 mg, 0.36 mmcl) were added to an oven dried vial, which was nitrogen purged for 10 minutes. DMSO (0.36and 2,2,6,6-tetramethyl-3,5-heptanedione (4 il, 0.019 mmcl) were then added. The reaction was heated at 40 C for three hours. The cooled mixture was diluted with EtOAc and washed thrice witha solution of 9:1 saturated NH4CI: NH4OH and then thrice with water and then brine. The organic layer was dried over Na2SO4, filtered and concentrated. The well dried solid was dissolved in methylene chloride and passed through a short silica plug, which removed the small amount of unreacted amine. The filtrate was condensed to give white solid, which was purified by automated flash chromatography system in 50-80 % methylene chloride/hexanes. Isolated yield = 61%, ee =96%. Recrystallization to enhance ee was carried out by heating a solution of 15.8 mg of purified product in 1.0 ml of isopropanol. Overall Yield = 59 %, ee = 98.5 %1H NMR (CDCI3, 400 MHz) :5 8.16 (d, J = 1.9 Hz, 2H), 7.56 (d, J = 1.9 Hz, 2H), 7.35 – (t, J = 7.8 Hz, 1H),7.30 (d, J = 8.7 Hz, 1H), 6.04 (dd, J = 32.7, 8.0 Hz, 2H), 5.29 -5.02 (dm, 1H), 4.65 -4.46 (m, 3H), 3.87- 3.74 (m, 1H), 3.70 (s,3H), 3.66 – 3.49 (m, 1H). ESI m/z: 506.7 ([Mi-1], C22H19Br2FN2O requires504.98
According to the analysis of related databases, 182275-70-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; UNIVERSITY OF IOWA RESEARCH FOUNDATION; MCKNIGHT, Steven L.; READY, Joseph M.; PIEPER, Andrew A.; WO2015/70234; (2015); A3;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem