The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 709652-82-4, name is 2-Amino-5-bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 709652-82-4
PREPARATION 16 PREPARATION OF (Z)-2-AMiNO-5-BROMO-N’-HYDROXYNicoTiNiMiD AMIDE A solution of 2-amino-5-bromopyridine-3-carbonitrile (2.00 g, 10.1 mmol), hydroxylamine hydrochloride (1.06 g, 15.3 mmol) and 24 mL of triethylamine in 40 mL of ethanol was refluxed for 3 h. The resulting mixture was poured into ice cold water to afford a white solid. The solid was separated by filtration and washed with water. The filtrate was extracted with ethyl acetate and the organic layers were combined, dried over anhydrous sodium sulfate and filtered. The filtrate was evaporate to afford a white solid which was combined with the white solid obtained earlier to afford (Z)-2-amino-N’-(benzoyloxy)-5-bromonicotinimidamide in quantitative yield (2.30 g). 1H NMR (400 MHz, OMSO-d6):S9.95 (s, 1H), 7.96 (d, J= 2.4 Hz, 1H), 7.89 (d, J= 2.4 Hz, 1H), 7.20 (br s, 2H), 5.93 (s, 2H).
With the rapid development of chemical substances, we look forward to future research findings about 709652-82-4.
Reference:
Patent; SIGNALCHEM LIFESCIENCES CORPORATION; ZHANG, Zaihui; WO2015/81257; (2015); A2;,
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