Adding a certain compound to certain chemical reactions, such as: 885588-12-5, 2-Bromo-5-fluoro-4-pyridinecarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 885588-12-5, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Bromo-5-fluoro-4-pyridinecarboxylic acid
To a cooled solution of 2-bromo-5-fluoroisonicotinic acid (3.0 g, 13.6 mmol) in benzene (20 ml) and methanol (10 ml) is dropwise over a period of 15 min added under stirring and cooling (trimethylsiliyl)diazomethane (2 M in ether, 14 ml, 28 mmol). The yellow solution is stirred for 1.5 h without cooling and evaporated to dryness. Purification of the residue (3.3 g) bychromatography on a 50 g Silicycle silica cartridge using a heptane / ethyl acetate 10-50% gradient affords methyl 2-bromo-5-fluoroisonicotinate (2.82 g, 88.4%) as a light yellow solid, mp.: 43 – 6C. MS: m/z= 233.9 (M+H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,885588-12-5, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; FLOHR, Alexander; GOBBI, Luca; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; PETERS, Jens-Uwe; WO2012/76430; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem