Related Products of 19346-43-1 ,Some common heterocyclic compound, 19346-43-1, molecular formula is C6H5FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2.52 g (0.015 mol) of 2-hydrazine-4-methyl-3-nitropyridine was added to 40 cm3 of n-propanol, 5 cm3 of water, 1 g of sodium bicarbonate and 2.34 g (0.015 mol of 2-fluoro-4-methyl-3-nitro-pyridine. The mixture was heated for 30 min under reflux on a water bath. The mixture changed its color to purple. Then it was evaporated to dryness under reduced pressure and the dry residue was added to 150 cm3 of water, acidified with dilute hydrochloric acid and allowed to stand at room temperature for 12 h. Then the reaction product was filtered and recrystallized with activated carbon. An insoluble product in a form of red-brown needle-shaped crystals was filtered off, dried and re-crystallized twice from ethanol. It was sparingly soluble in water and organic solvents, soluble in glacial acetic acid. The melting point of MNHP was determined giving the value 255 C. More details (e.g. the yield and the chemical analysis) of the synthesis can be found in our publications [16,19].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19346-43-1, 2-Fluoro-3-nitro-4-picoline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kucharska; Bryndal; Hanuza; Lis; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 127; (2014); p. 303 – 309;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem