Reference of 65515-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65515-39-1, name is 2-Methoxy-4,6-dimethylnicotinonitrile, molecular formula is C9H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(a) 4-(but-3-en-l-yl)-2-methoxy-6-methylnicotinonitrile To a solution of 2-methoxy-4,6-dimethylnicotinonitrile (1.5 g, 9.25 mmol) in THF (40 mL) was added LiHMDS (10.17 mL, 10.17 mmol) at -78 C, and the mixture was stirred at -78 C for 1 h. 3-Bromoprop-l-ene (0.880 mL, 10.17 mmol) was added and the mixture was stirred at -78 C for 1 h and warmed to 0 C over 1 h. The mixture was then stirred at 0 C for 3 h. The reaction was quenched with saturated aqueous H4C1 solution and extracted with EtOAc (3x). The combined organics were dried over Na2SC”4 and concentrated. The residue was purified using reverse phase HPLC using Trilution software, with a phenomenex Gemini 5u CI 8(2) 100 A, AXIA 30×100 mm 5 micron, 10- minute run (30 mL/min, 40% CH3CN/H20, 0.1% formic acid to 80% CH3CN/H20, 0.1% formic acid) with UV detection at 254 nm to afford 4-(but-3-en-l-yl)-2-methoxy-6- methylnicotinonitrile (1.01 g, 54%) as a pale yellow oil. LC-MS(ES) m/z = 203 [M+H]+.
According to the analysis of related databases, 65515-39-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; KNIGHT, Steven David; LAFRANCE, Louis Vincent III; MCNULTY, Kenneth C.; ROMERIL, Stuart Paul; SEEFELD, Mark Andrew; WO2014/195919; (2014); A1;,
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