With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.184416-84-0, name is 2,3-Dichloroisonicotinic acid, molecular formula is C6H3Cl2NO2, molecular weight is 192, as common compound, the synthetic route is as follows.Application In Synthesis of 2,3-Dichloroisonicotinic acid
A mixture of 2,3-dichloroisonicotinic acid (960 mg, 5.00 mmol) and BH3 FontWeight=”Bold” FontSize=”10″ THF (1.0 M, 25 mL, 25 eq) was heated at 60 C for 4 h. After cooling to RT, MeOH (5 mL) was added, and the volatiles were removed under reduced pressure. The reaction mixture was diluted with water (50 mL) and extracted with DCM (50 mL x 3). The combined organic phase was washed with brine (100 mL), dried over Na2SC>4, filtered and concentrated to give (2,3- dichloropyridin-4-yl)methanol (400 mg, 45%) as a white solid. MS (ES+) C6H5C12N0 requires: 178, found: 179 [M+H]+. XH NMR (500 MHz, i-DMSO) delta 8.38 (d, J = 5 Hz, 1H), 7.58 (d, J= 5 Hz, 1H), 5.85-5.75 (br s, 1 H), 4.61 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,184416-84-0, 2,3-Dichloroisonicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; TESARO, INC.; JONES, Philip; CZAKO, Barbara; BURKE, Jason P.; CROSS, Jason; LEONARD, Paul Graham; TREMBLAY, Martin; MANDAL, Pijus; (232 pag.)WO2018/119387; (2018); A1;,
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