Electric Literature of 175422-04-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 175422-04-5, name is 2,6-Dibromo-4-nitropyridine. A new synthetic method of this compound is introduced below.
The solution of 2,6-dibromo-4-nitropyridine (0.4 g, 1.419 mmol) and 1, 2,3,4- tetrahydroisoquinoline (0.378 g, 2.84 mmol) in dioxane (2 mL) was stirred at 100 C for 14 h. The reaction mixture was concentrated under reduced pressure and the residue so obtained was purified through silica gel column chromatography by using 10-30% ethyl acetate and pet ether as an eluant to afford 91 A (brown solid, 0.75 g, 1.369 mmol, 48.3 % yield). LC-MS Anal.Calc?d for Ci4Hi2BrN302 333.0, found [M+2] 335.0 Tr = 3.76 min (Method N).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,175422-04-5, 2,6-Dibromo-4-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; MARKWALDER, Jay A.; SHAN, Weifang; WILLIAMS, David K.; NARA, Susheel Jethanand; ROY, Saumya; THANGAVEL, Soodamani; CHERUKU, Srinivas; SISTLA, Ramesh Kumar; (230 pag.)WO2020/23355; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem