Related Products of 122851-69-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 122851-69-8, name is 3-Bromo-2-(chloromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of cis-4-(2-methoxyphenyl)cyclohexanol (889 mg) in THF (20 ml) wasadded 60% sodium hydride (345 mg) at 0C, and the mixture was stirred at under anitrogen atmosphere at room temperature for 2 hr. To the reaction mixture was added3-bromo-2-(chloromethyl)pyridine (1.16 g), and the mixture was stirred at room temperaturefor 2 hr, and at 70C for 3 hr. To the reaction mixture was added water, andthe mixture was extracted with ethyl acetate. The obtained organic layer was washedsuccessively with water and saturated brine, dried over anhydrous magnesium sulfate,and the solvent was evaporated under reduced pressure. The residue was purified bysilica gel column chromatography (ethyl acetate/hexane) to give the title compound(743 mg).MS, found: 376.0,378.0.
According to the analysis of related databases, 122851-69-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FUJIMOTO Tatsuhiko; RIKIMARU Kentaro; FUKUDA Koichiro; SUGIMOTO Hiromichi; MATSUMOTO Takahiro; TOKUNAGA Norihito; HIROZANE Mariko; (166 pag.)WO2017/135306; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem