Application of 36178-05-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36178-05-9, name is 3-Bromo-2-fluoropyridine, molecular formula is C5H3BrFN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A 60% dispersion of sodium hydride in mineral oil (7.4 g, 184.6 mmol) was suspended in anhydrous tetrahydrofuran (300 mL) under nitrogen. Absolute ethanol (10.0 mL, 170.4 mmol) was added dropwise at room temperature and the reaction mixture was stirred for 40 minutes at room temperature. 2-Fluoro-3-bromopyridine (25.0 g, 142.0 mmol) was added and the reaction mixture was stirred for 3 hours at room temperature. Water (250 mL) was added and the organic layer was separated. The aqueous layer was extracted with ethyl acetate (2 x 200 mL). The organic layers were combined, dried over sodium sulfate, filtered and concentrated in vacuo to afford the title compound as a light yellow oil (31 .5 g, 84%). 1H NMR (400MHz, CDCl3): delta ppm 1.43 (m, 3H), 4.43 (m, 2H), 6.74 (m, 1 H), 7.79 (m, 1 H), 8.07 (m, 1 H). LCMS Rt = 2.45 minutes MS m/z 203 [MH]+
According to the analysis of related databases, 36178-05-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER LIMITED; STORER, Robert, Ian; SWAIN, Nigel, Alan; WO2013/93688; (2013); A1;,
Pyridine – Wikipedia,
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