The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 103577-66-8, name is (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H10F3NO2
f) 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride 160 ml of toluene were added to 14.9 g (0.067 mole) of 2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine in methylene chloride followed by distillation of methylene chloride. The solution was purified with 2.7 g of acivated charcoal, filtered and washed with 36 ml of toluene. To this solution 5.4 ml (0.075 mole) of thionyl chloride in 27 ml of toluene were added dropwise and maintained for 3 hours. The gas was removed under vacuum at room temperature, then the resulting mixture was cooled to a temperature of from 0 to 5°C and stirred for one hour. The product was filtered, washed with 3 ml of toluene and dried in a vacuum dryer at 35-40°C. The yield was 15.65 g (84 percent).
With the rapid development of chemical substances, we look forward to future research findings about 103577-66-8.
Reference:
Patent; Krka Tovarna Zdravil, D.D., Novo Mesto; EP1681056; (2006); A1;,
Pyridine – Wikipedia,
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