The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 956010-87-0, name is 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
To compound 12 (50 mg, 0.27 mmol) and 2-aminophenol (35 mg, 0.32 mmol) was added a 1N aqueous sodium hydroxide solution (0.75 mL), and the mixture was heated in a microwave oven to 150 C for 10 min. It was then diluted with water and extracted twice with ethyl acetate. 4N HCl solution was added (pH 4), and the mixture was extracted again with ethyl acetate. The combined organic layers were dried over sodium sulfate, and the solvent was evaporated. The residue was purified by preparative HPLC to yield 52 mg (82%) of the title compound as a tan solid. 1H NMR (400 MHz, DMSO-d6): delta 7.44-7.52 (m, 3H), 7.89 (t, J=8.4Hz, 2H), 8.71 (d, J=4.4Hz, 1H), 8.76 (d, J=8.1Hz, 1H), 14.42 (br s, 1H). 13C NMR (125 MHz, DMSO-d6): delta 111.0, 113.3, 118.9, 119.8, 125.0, 125.8, 130.4, 131.9, 141.1, 149.5, 150.1, 152.3, 157.4. HRMS m/z calcd for C13H8N4O: 236.0698; found: 236.0698.
With the rapid development of chemical substances, we look forward to future research findings about 956010-87-0.
Reference:
Article; Schirok, Hartmut; Griebenow, Nils; Fuerstner, Chantal; Dilmac, Alicia M.; Tetrahedron; vol. 71; 34; (2015); p. 5597 – 5601;,
Pyridine – Wikipedia,
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