Application of 22245-83-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22245-83-6, name is 3-(Trifluoromethyl)pyridin-2-ol. A new synthetic method of this compound is introduced below.
EXAMPLE 12APreparation of compound 2003Step 1 :To a mixture of 2-hydroxy-3-triotafluoromethylpyridine 12a1 (39.01 g, 239 mmol) and anhydrous DMF (800 ml_) under Ar is added lambda/-iodosuccinimiotade (4.89 g, 244 mmol) and anhydrous K2CO3 (33.72 g, 244 mmol) and the mixture is allowed to stir at 600C for about 3 hours. The mixture is cooled to ambient temperature, filtered and concentrated under reduced pressure. The residue is dissolved in DCM (1 L) and the organic phase is washed with brine The aqueous phase is adjusted to pH 4 by the addition of 2 M HCI then extracted with DCM (1 L). The combined organic extracts are washed with brine (2 L) and dried over Na2SO4 The mixture is concentrated to ~300 mL and cooled overnight in a fridge. The precipitated solid is removed by filtration and dried to provide aryl iodide 12a2
At the same time, in my other blogs, there are other synthetic methods of this type of compound,22245-83-6, 3-(Trifluoromethyl)pyridin-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/18657; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem