Synthetic Route of 53937-02-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone, molecular formula is C12H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
B) 4- (Benzyloxy) -1- (2-ethyl-l-methyl-lH-benzimidazol-6- yl) pyridin-2 ( 1H) -one A mixture of 4-benzyloxy-2 ( 1H) -pyridone (1 g) , 6-bromo-2- ethyl-l-methyl-lH-benzimidazole (1.19 g) , Nu,Nu’- dimethylethylenediamine (0.530 ml), copper (I) iodide (0.946 g) , potassium carbonate (2.06 g) and DMSO (20 ml) was stirred at 150C for 2 h. The mixture was added to 28% NH3 solution, and the precipitate was collected. The solid was dissolved in THF, passed through NH silica pad and concentrated in vacuo to give the title compound (986 mg) as a pink solid. A part of the target compound was treated with activated carbon and recrystallized from THF to give 46.1 mg of the title compound as a white solid. . MS (ESI+) : [M+H]+ 360.4. XH NMR (400 MHz, DMSO-d6) : delta 1.33 (3H, t, J = 7.4 Hz), 2.90 (2H, q, J = 7.5 Hz), 3.74 (3H, s), 5.16 (2H, s), 5.98 (1H, s) , 6.10 (1H, d, J = 5.4 Hz), 7.07 (lH, d, J = 8.8 Hz), 7.34-7.51 (5H, m) , 7.53 (1H, s) , 7.55-7.62 (2H, m)
According to the analysis of related databases, 53937-02-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti; WO2013/105676; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem