The important role of 4-Bromo-2-chloropyridine

The chemical industry reduces the impact on the environment during synthesis 73583-37-6, I believe this compound will play a more active role in future production and life.

Application of 73583-37-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73583-37-6, name is 4-Bromo-2-chloropyridine, molecular formula is C5H3BrClN, molecular weight is 192.44, as common compound, the synthetic route is as follows.

To a solution of 4-bromo-2-chloropyridine (1.91 g, 10 mmol) in THF (25 mL) was added isopropyl magnesium chloride (1.3 M in THF, 9 ml, 12 mmol) dropwise at 0 C. The mixture stirred at rt for 1 hour then a solution of 3-methylcyclohexanone (1.68 g, 15 mmol) in THF (5 mL) was added dropwise. The reaction was stirred overnight then quenched with saturated ammonium chloride. The mixture was partitioned between EtOAc and water. The organic layer was washed with brine, dried ( a2S04) and concentrated under reduced pressure. The residue was purified via column chromatography on silica gel (petroleum ether/EtOAc= 10: 1) to give l-(2-chloropyridin-4-yl)-3-methylcyclohexanol (0.8 g, 36 %) as light yellow oil. MS ESI calc’d. For Ci2H16ClNO [M + H]+ 226 found 226.

The chemical industry reduces the impact on the environment during synthesis 73583-37-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ANDRESEN, Brian, M.; ANTHONY, Neville, J.; MILLER, Thomas, A.; WO2014/74422; (2014); A1;,
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