In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 887583-90-6, name is 4-Bromo-2-(trifluoromethyl)pyridine, the common compound, a new synthetic route is introduced below. name: 4-Bromo-2-(trifluoromethyl)pyridine
To a solution of 4-bromo-2- (trifluoromethyl) pyridine (190 g, 840.7 mmol) in THF (1300 mL) cooled to 0 under nitrogen was added isopropylmagnesium chloride (THF, 2N, 462mL, 924.8 mmol) dropwise over 30 min while maintaining the temperature below 5 . After addition, the mixture was stirred below 10 for 30 min and recooled to 0 . Acetaldehyde (55.48 g, 1261 mmol) was added dropwise while maintaining the temperature below 10 . After addition, the mixture was stirred below 10 for 30 min before quenching with aqeous NH4Cl (saturated, 500mL) . The mixture was concentrated in vacuo to remove most THF. The aqueous phase was extracted with EtOAc (1.0 L ¡Á 3) . The combined organic extracts were washed with H2O (500 mL ¡Á 3) , brine (500 mL ¡Á 2) , dried over anhydrous sodium sulfate, filtered off, and concentrated in vacuo to give the crude title compound (150 g, yield: 93%) , which was used in the next step without further purification..
The synthetic route of 887583-90-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JS INNOPHARM (SHANGHAI) LTD; ZHANG, Jintao; XU, Wen; JIAN, Shanzhong; LI, Qun; (166 pag.)WO2019/37640; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem