Adding a certain compound to certain chemical reactions, such as: 877133-54-5, 4-Bromo-2,6-diethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 877133-54-5, blongs to pyridine-derivatives compound. SDS of cas: 877133-54-5
-Bromo-2,6-diethylpyridine (2.9 g, 13.55 mmol), dichlorobis(trirhohenylphosphine)palladium (477 mg, 0.68 mmol) and copper(I) iodide (130 mg, 0.68 mmol) were placed in a vial and flushed with argon. Ethynyl(trimethyl)silane (2.34 mL, 16.9 mmol) and anhydrous lambdazetaiV-dimethylformamide (20 mL) were added followed by diisoproylamine (5.75 mL, 40.7 mmol). The reaction was divided into two 25 mL vials and irradiated in a microwave at 100 0C for 15 min. Water was added and the mixture was extracted with dichloromethane. The combined organic phases were concentrated in vacuo and purified by column chromatography, using a gradient of ethyl acetate (0 to 30%) in r°-heptane as the eluent, to give 1.64 g (63% yield) of the title compound: MS (ESI) m/z 111 [M+l]+.
The synthetic route of 877133-54-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2008/76046; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem