Adding a certain compound to certain chemical reactions, such as: 73583-41-2, 4-Bromo-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 73583-41-2, blongs to pyridine-derivatives compound. Recommanded Product: 4-Bromo-3-chloropyridine
Step c: To a solution of tert-butyl (i-(6-amino-5-mercaptopyrazin-2-yl)-4-methylpiperidin-4-yl)carbamate(44 mg, 0.130 mmol), 4-bromo-3-chloropyridine (31.2 mg, 0.162 mmol), XantPhos (7.5 mg, 0.013 mmol), and Pd2 (dba)3 (5.9 mg, 0.0065 mmol) in dioxane (2 mL) was added (at RT and under N2) DIPEA (68 IL, 0.389 mmol). The resulting solution was stirred in a microwave reactor for 1 h at 110 C. and for 1 h at 125 C. After cooling to RT, the reaction was diluted with EtOAc and it was filtered through a pad of Celite followed by EtOAc (5 mL) wash. The volatiles were removed under reduced pressure. The result-ing residue was dissolved in DCM (3 mE) and it was treated with TFA (500 IL). The resulting mixture was stirred for 10 mm at RT. The volatiles were removed under reduced pressure and the resulting residue was purified by HPLC (gradient elution 15-40% acetonitrile in water, 5 mM NH4OH modifier) to give 6-(4-amino-4-methylpiperidin-1 – yl)-3-((3-chloropyridin-4-yl)thio)pyrazin-2-amine (8.5 mg, 0.024 mmol). ?H NMR (400 MHz, METHANOL-d4) oe 8.30 (s, 1H), 8.06 (d, J=5.56 Hz, 1H), 7.52 (s, 1H), 6.58 (d, J=5.31 Hz, 1H), 3.76 (ddd, J=13.64, 7.07, 4.29 Hz, 2H), 3.44-3.59 (m, 2H), 1.45-1.64 (m, 4H), 1.09-1.23 (m, 3H). HRMS calcd for C,5H2QC1N65 (M+H) 351.1159. found 351.1159. IC50 is 0.076 tM.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73583-41-2, its application will become more common.
Reference:
Patent; NOVARTIS AG; Chen, Zhuoliang; Dore, Michael; Fortanet, Jorge Garcia; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Williams, Sarah; Sendzik, Martin; (63 pag.)US2017/1975; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem