Related Products of 850663-54-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 850663-54-6, name is 4-Chloro-5-nitropyridin-2(1H)-one, molecular formula is C5H3ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-Chloro-2-hydroxy-5-nitropyridine (17.2 g, 98.6 mmol) was suspended in toluene (150 mL) before careful addition of phosphorus oxychloride (28 mL, 300 mmol) over 20 minutes. The reaction mixture was heated to reflux for 6 h before cooling to 60 C and stirring for a further 15 h. The reaction mixture was cooled to ambient temperature and then concentrated to dryness under vacuum to give a dark brown oil which was carefully basified at 0 C with sat. K2CO3 (?60 mL). The mixture was extracted with AcOEt (3 x 200 mL). The combined organic phases were quickly washed with water and then brine before drying over Na2SO4. The solvents were removed under vacuum to give a dark brown oil which was purified by passing through a plug of silica, (eluting with petrol ? 1:1, petrol: AcOEt) to give the product as a pale yellow powder (12.2 g, 64%). 1H NMR (400 MHz, CDCl3) delta (ppm): 9.0 (1 H, s), 7.6 (1 H, s). LC-MS: Rt = 2.44 min.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 850663-54-6, 4-Chloro-5-nitropyridin-2(1H)-one.
Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel (Prof. Dr.); Falcenberg, Mathias (Dr.); EP2818472; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem