Application of 4214-74-8 , The common heterocyclic compound, 4214-74-8, name is 3,5-Dichloropyridin-2-amine, molecular formula is C5H4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1: 2-bromo-3,5-dichloropyridine [0239] To a solution of 3,5-dichloropyridin-2-amine (1.0 g, 6.2 mmol) in 40% aqueous HBr (8 mL) was added dropwise bromine (2.8 g, 17 mmol) at -20C. The orange suspension was stirred for 2hrs at -20C, and followed by addition of the aqueous NaN02 (1.1 g, 17 mmol) at -20C. The mixture thus obtained was stirred for an additional 2 hours at ambient temperature. The brown mixture was basified with 30% aqueous NaOH to pH ~12 at 0C. The pale yellow mixture was extracted with ether. The combined organic phases were washed with brine, dried over Na2S04 and concentrated to afford the title compound as yellow solid (730 mg, 52%). 1H NMR (400 MHz, CDC13) delta 8.27 (d, J J= 2.3 Hz, 1H).
The synthetic route of 4214-74-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (119 pag.)WO2015/187845; (2015); A1;,
Pyridine – Wikipedia,
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