Reference of 757978-18-0 ,Some common heterocyclic compound, 757978-18-0, molecular formula is C7H4BrIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
60% NaH in oil (150 mg, 3.74 mmol) was added to a solution of 5-bromo-3-iodo-lH- pyrrolo[2,3-b]pyridine (1.0 g, 3.12 mmol) in dry DMF (6 mL) at 00C. The reaction mixture was allowed to warm to rt over 1 h and cooled again to 0 0C. 2-(chloromethoxy)ethyl)trimethylsilane (661 uL, 3.74 mmol) was then added and the reaction was maintained for 1.5 h. The reaction was then quenched with water and the mixture was concentrated in vacuo. The resulting crude solid was dissolved in EtOAc (75 mL) and washed sequentially with water (2 X 25 mL), aqueous 2.0 M HCl (50 mL), water (25 mL), and then brine (50 mL). The solution was dried (Na2SO^ and concentrated to yield 1.48 g of 5-bromo-3-iodo-l-((2-(trimethylsilyl)ethoxy)methyl)-lH-pyrrolo[2,3,-delta]pyridine:LCMS (m/z): 455.0 (MH+), tR= 1.47 min .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 757978-18-0, 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; WO2009/115572; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem