Application of 74115-13-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74115-13-2, name is 5-Bromo-3-pyridinol. This compound has unique chemical properties. The synthetic route is as follows.
In an argon atmosphere, potassium carbonate (1.6 g, 11.3 mmol) was added to a N,N-dimethylformamide (15 mL) solution of 3-bromo-5-hydroxypyridine (980 mg, 5.6 mmol) and 2-fluoroethyl-4-methylbenzenesulfonate (1.2 ml, 6.8 mmol) under stirring at room temperature (25 C.), and the mixture was stirred at the same temperature as above for 10 minutes and then stirred at 70 C. for 8 hours. After the completion of the reaction, distilled water was added to the reaction mixture, followed by extraction four times with diethyl ether. The extract was washed with saturated saline and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off, and the obtained crude product was purified by silica gel column chromatography (ethyl acetate:hexane (volume ratio)=1:5) to obtain compound 10 (1.0 g, yield relative to 3-bromo-5-hydroxypyridine: 82%) in a pale yellow liquid form.Compound 10: 1H-NMR delta: 8.28 (d, 1H), 8.22 (d, 1H), 7.30 (t, 1H), 4.75 (t, 1H), 4.60 (t, 1H), 4.28 (t, 1H), 4.17 (t, 1H)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74115-13-2, 5-Bromo-3-pyridinol.
Reference:
Patent; Nihon Medi-Physics Co., Ltd.; Kyoto University; Saji, Hideo; Kimura, Hiroyuki; Ono, Masahiro; Matsumoto, Hiroki; US2014/187784; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem