Electric Literature of 90145-48-5 ,Some common heterocyclic compound, 90145-48-5, molecular formula is C6H5BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 2 tert-Butyl 2-(6-carbamoylpyridin-3-yl)-5-fluoro-lH-indole-l-carboxylatel-(t°t-Butoxycarbonyl)5-fiuoroindole-2-boronic acid (1 mmol), 5-bromopyridine-2- carboxamide (lmmol), Pd(dppf)Cl2 (0.05 mmol) and 2M Na2CO3 (aq.) (1.5 mL) solution were mixed in THF/water 5:1 (10 mL) in a 20 mL microwave vial. The reaction mixture was stirred at 1200C in the microwave reactor for 15 min. Water was added and the solution was extracted with EtOAc. The organic extracts were dried over Na2SO4, filtered and concentrated to afford a crude mixture which was purified by flash chromatography
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,90145-48-5, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; WO2008/108729; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem