The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 101990-70-9, name is 5-(Chloromethyl)-2-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H8ClNO
3,7-Dimethyl-1H-purine-2,6(3H,7H)-dione (300 mg, 1.67 mmol) was dissolved in N,N-dimethylformamide (10 mL), and 5-(chloromethyl)-2-methoxypyridine (263 mg, 1.67 mmol), potassium iodide (332 mg, 2.00 mmol) and potassium carbonate (461 mg, 3.34 mmol) were added. The reaction solution was heated to 120C, stirred for 3 hours and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (1:1 petroleum ether / ethyl acetate, Rf = 0.2) to give 1-((6-methoxypyridin-3-yl)methyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione (20.0 mg) with a yield of 4%. 1H NMR: (400 MHz, CDCl3) delta 8.28(s, 1H), 7.78(d, J = 8.0 Hz, 1H), 7.51(s, 1H), 6.67(d, J = 8.0 Hz, 1H), 5.12(s, 2H), 3.99(s, 3H), 3.91(s, 3H), 3.57(s, 3H). MS-ESI calcd. [M + H]+ 302, found 302.
With the rapid development of chemical substances, we look forward to future research findings about 101990-70-9.
Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Lingyun; CHEN, Xiaoxin; ZHANG, Peng; LIU, Xing; ZHANG, Li; LIU, Zhuowei; CHEN, Shuhui; LONG, Chaofeng; (160 pag.)EP3299371; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem