Adding a certain compound to certain chemical reactions, such as: 101990-70-9, 5-(Chloromethyl)-2-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 101990-70-9, blongs to pyridine-derivatives compound. Product Details of 101990-70-9
To a stirred solution of compound 2 (400 mg, 1.79 mmol) in DMF (4 mL) at 0 C, was added NaH (90 mg of a 60% dispersion in mineral oil, 2.25 mmol). The mixture was warmed to RT and stirred for 20 mm. The mixture was cooled to 0 C, and a solution of 5-(chloromethyl)-2- methoxypyridine (310 mg, 1.97 mmol) in DMF (1 mL) was added. The mixture was allowed to warm to RT and stirred for a further 16 h. The mixture was partitioned between water (50 mL)and EtOAc (30 mL). The organic layer was separated and the aq. layer re-extracted with additional EtOAc (30 mL). The combined organic layers were dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure. The residue was purified (silica gel; eluting with 0-100% EtOAc in hexanes), to afford compound 3 (580 mg, 85%) as a colorless oil. LCMS Mass: 345.0 (M+1).
The synthetic route of 101990-70-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin, W.; HUTCHINSON, John, Howard; (185 pag.)WO2017/3862; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem