Synthetic Route of 15069-92-8, Adding some certain compound to certain chemical reactions, such as: 15069-92-8, name is 5-Hydroxypicolinic acid,molecular formula is C6H5NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15069-92-8.
A mixture of 5-hydroxypicolinic acid (10.0 g, 71.9 mmol), silver carbonate (79 g, 288.0 mmol), and methyl iodide (18.0 ml, 288.0 mmol) in acetonitrile (350 ml) was stirred at rt for 24 hours. Solids were removed through vacuum filtration and washed with ethyl acetate (3 x 80 ml). Filtrate was reconcentrated in vacuo, and the residue was purified by flash chromatography on silica gel using ethyl acetate and hexanes to afford the title compound as a light brown solid (7.2 g, 60% yield). ?H NMR is consistent with ?H NMR of commercially available 5-methoxypyridine-2-carboxylic acid methyl ester.
According to the analysis of related databases, 15069-92-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Koay, Natalie; Tonelli, Devin L.; Truong, Vouy Linh; Tetrahedron Letters; vol. 52; 1; (2011); p. 122 – 124;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem