Reference of 80194-69-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 80194-69-0 as follows.
2-Phenoxyaniline (0.185 g, 1.0 mmol), 5-Trifluoromethyl-2-pyridinecarboxylic acid (0.191 g, 1.0 mmol) was dissolved in 30 mL of dichloromethane. Add triethylamine (0.202 g, 2.0 mmol), then EDCI (0.287 g, 1.5 mmol) was added. HOBt (0.20g, 1.5mmol), After reacting at 25 C for 6 h, after the reaction was completed by TLC, the reaction solution was washed three times with water. The organic layer was collected and the organic layer was dried over anhydrous sodium sulfate. Desolvation, the crude product was purified by column chromatography to give a dark green solid. M.p. 78-80 C, yield 92%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,80194-69-0, its application will become more common.
Reference:
Patent; Shanghai Kaiai Network Technology Co., Ltd.; Xu Liyong; (7 pag.)CN108516955; (2018); A;,
Pyridine – Wikipedia,
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