The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctan-1-ol( cas:50816-19-8 ) is researched.Product Details of 50816-19-8.Piras, Monica; Patruno, Ilaria; Nikolakopoulou, Christina; Willment, Janet A.; Sloan, Nikki L.; Zanato, Chiara; Brown, Gordon D.; Zanda, Matteo published the article 《Synthesis of the Fungal Metabolite YWA1 and Related Constructs as Tools to Study MelLec-Mediated Immune Response to Aspergillus Infections》 about this compound( cas:50816-19-8 ) in Journal of Organic Chemistry. Keywords: YWA1 fonsecin B derivative synthesis melLec immune response Aspergillus. Let’s learn more about this compound (cas:50816-19-8).
We describe the chem. synthesis of the fungal naphthopyrones YWA1 (I) and fonsecin B (II), as well as their functionalization with an amine-spacer arm and the conjugation of the resulting mols. to three different functional tags (i.e., biotin, Oregon green, 1-[3-(succinimidyloxycarbonyl)benzyl]-4-[5-(4-methoxyphenyl)-2-oxazolyl]pyridinium bromide (PyMPO)). The naphthopyrone-biotin and -PyMPO constructs maintained the ability to bind the C-type lectin receptor MelLec, whose interaction with immunol. active fungal metabolites (i.e., 1,8-dihydroxynaphthalene-(DHN)-melanin and YWA1) is a key step in host recognition and induction of protective immune responses against Aspergillus fumigatus. The fluorescent Fonsecin B-PyMPO construct III was used to selectively visualize MelLec-expressing cells, thus validating the potential of this strategy for studying the role and functions of MelLec in immunity.
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