As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52718-95-3, name is Methyl 2-bromonicotinate, molecular formula is C7H6BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Methyl 2-bromonicotinate
1,3-Benzene-diboronic acid (0.66 g, 3.99 mmol), compound 6 (1.80 g, 8.37 mmol), K2CO3 (1.10 g, 7.97 mmol) and Pd(dppf)Cl2 (0.146 g, 0.2 mmol) were dissolved in a degassed mixture of THF/water (20 mL/4 mL). The mixture was heated to 70C and stirred overnight under N2. After cooling to room temperature, saturated solution of chloride ammonium (100 mL) was added, and aqueous layer was extracted with dichloromethane (3×50 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether:ethyl acetate=5:1; V/V) to give the compound 7 as a colorless oil (1.03 g, 74%).
With the rapid development of chemical substances, we look forward to future research findings about 52718-95-3.
Reference:
Article; Tan, Shuai; Wu, Xiugang; Zheng, Yanqiong; Wang, Yafei; Chinese Chemical Letters; vol. 30; 11; (2019); p. 1951 – 1954;,
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