571188-59-5, Adding a certain compound to certain chemical reactions, such as: 571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 571188-59-5, blongs to pyridine-derivatives compound.
In a 250 ml round bottom flask,Was added 2-chloro-7-cyclopentyl–N, N- dimethyl–7H- pyrrolo [2,3-d] pyrimidine-6-carboxamide and 14.6g (50mmol),Tert-Butyl 4- (6-aminopyridin-3-yl) piperazine-1-carboxylate15.3 g (55 mmol),0.67 g (3 mmol) of Pd (OAc) 2,BINAP 1.2 g (2 mmol),Cs2CO3 65.1g (200mmol) and 130ml 1,4-dioxane, warmed to 90 C, the reaction was stirred for 8 hours,The reaction was monitored, concentrated under reduced pressure and flash column chromatographyA solution of 4- (6- (7- (dimethylcarbamoyl) -7H-pyrrolo [2,3-d] pyrimidin- 2-ylaminopyridin-3-yl) – carboxylic acid tert-butyl ester.The above obtained solution of 4- (6- (7- (dimethylcarbamoyl) -7H-pyrrolo [2,3-d] pyrimidin- 2-ylaminopyridin-3-yl) – carboxylic acid tert-butyl esterDissolved in 100ml of toluene,Add 30ml 6mol / L hydrochloric acid, and stirred at room temperature for 2 hoursThe reaction was monitored completely, adjusted to pH 8 with sodium hydroxide, extracted with methylene chloride, washed with brine and driedThe organic phase was dried over sodium sulfate, concentrated under reduced pressure,N-hexane to obtain Ribociclib 18.2g, the yield was 83.7%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,571188-59-5, its application will become more common.
Reference:
Patent; Tsingtao Chenda Biological Technology Co., Ltd.; Chen Linghao; (8 pag.)CN106928236; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem