With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58584-86-4, name is Ethyl 2,6-dichloronicotinate, molecular formula is C8H7Cl2NO2, molecular weight is 220.05, as common compound, the synthetic route is as follows.Application In Synthesis of Ethyl 2,6-dichloronicotinate
Step 2: ethyl 6-chloiO-2-ethoxynicotinate; To a solution of ethyl 2,6-dichloronicotinate (5.0 g, 22.72 mmol) in dichloromethane (25 ml_) at 00C was added sodium ethoxide (2.12 g, 29.5 mmol) slowly. The reaction was stirred at 00C for 3 h and then warmed to ambient temperature over 16 h. The reaction was diluted with dichloromethane (20 ml_) and water (20 ml_) and the layers were separated. The aqueous layer was extracted an additional time with dichloromethane (20 ml_). The organic layers were combined, washed with brine (20 ml_), dried over magnesium sulfate, filtered, and concentrated to give the title compound (4.38 g, 84%) as a light yellow solid. 1 H NMR (400 MHz, DMSO-Cf6) delta ppm 1.22 – 1.40 (m, 6 H) 4.27 (q, J=7.03 Hz, 2 H) 4.37 (q, J=7.03 Hz, 2 H) 7.18 (d, J=8.00 Hz, 1 H) 8.15 (d, J=8.00 Hz, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,58584-86-4, Ethyl 2,6-dichloronicotinate, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; ARHANCET, Graciela Barbieri; CASIMIRO-GARCIA, Agustin; CHEN, Xiangyang; HEPWORTH, David; MEYERS, Marvin Jay; PIOTROWSKI, David Walter; RAHEJA, Raj Kumar; WO2010/116282; (2010); A1;,
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