Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6188-23-4, name is 6-Bromoimidazo[1,2-a]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 6188-23-4
Step 1: To a solution of 4-(ethoxycarbonyl)-3-fluorophenylboronic acid ( 1.29 g, 6.091 mmol), K3P04 (3.22 g, 15.22 mmol) in 1,4-dioxane (20 mL), and water (3 mL) was added 6- bromoimidazo[l,2-a]pyridine (1 g, 5.07 mmol) and degassed with argon for 30 min. (A- Phos)2PdCl2 (293 mg, 0.25 mmol) was added and again degassed with argon for 30 min and the reaction mixture was heated at 90 C for overnight. The reaction mixture was washed with water. The organic layer was concentrated and the crude product was purified by column chromatography (silica gel, eluent CHCl3/MeOH 96.5: 3.5) to afford 2-fluoro-4- (imidazo[l,2-a]pyridin-6-yl)benzoate (1.16 g, 81%, AUC LC-MS 84%). 1H NMR (300 MHz, DMSO- 6) ppm delta 9.1 (s, 1 H), 7.9 (m, 2 H), 7.6 (m, 5 H), 4.3 (q, J= 6.9 Hz, 2 H), 1.3 (t, J= 6.9 Hz, 3 H); MS (ESI) m/z 285 (M+l).
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Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
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