Application of 122306-01-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 122306-01-8, name is (6-Bromopyridin-3-yl)methanol. A new synthetic method of this compound is introduced below.
Step 1A solution of (beta-bromopyridin-3-yl) methanol (2.39 g) described in a reference (Ellingboe, J. W. et al. J. Med. Cheralpha. 1994, 37, 542-550.) in THF (65 mL) was ice-cooled, thionyl chloride (4.64 mL) was added, and the mixture was stirred at 0C for 6 hr. The reaction mixture was concentrated under reduced pressure. Toluene was added and the mixture was concentrated again, and dried under reduced pressure to give 2-bromo-5- (chloromethyl) pyridine hydrochloride (2.54 g) as a brown solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,122306-01-8, (6-Bromopyridin-3-yl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/119880; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem